Open access
Jul 2026
IFN-α and IFN-β inhibit NLRP1-driven PANoptosis.
Pathogens, tissue damage, and cellular stress are detected by innate immune sensor molecules to drive inflammatory signaling and cell death. Mutations in the sensor NLRP1 are associated with inflammatory disease, but the regulation of this sensor is not well understood. Here, we find that LPS, a TLR4 ligand and canonic...
B. Sharma, Harisankeerth Mummareddy, S. Chadchan et al.
· EMBO Reports · 1 citation