Author

Ron O. Dror

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Open access Aug 2026

Structural basis for nutrient-activated channel opening in bacterial spore germination receptors

GerA-family germinant receptors were recently identified as ion channels that initiate germination of dormant bacterial spores in response to nutrients. Here we report 2.0-Å cryo-electron microscopy structures of apo, agonist-bound, and antagonist-bound GerA, revealing a symmetric pentamer of heterotrimers. Signaling r...

Joshua C. Cofsky, Fernando H. Ramírez-Guadiana, Briana L. Sobecks-Doherty et al. · bioRxiv · 0 citations

Open access Sep 2026

Mechanism of gating and isoform-specific inhibition in renal CLC chloride channels.

Hyponatremia is a prevalent disorder marked by excess water retention and substantial morbidity, motivating interest in the chloride channel CLC-Ka as a therapeutic target. Selectively inhibiting CLC-Ka without affecting the closely related CLC-Kb is essential for preventing serious side effects. However, developing is...

Chih-Ta Chien, Briana L. Sobecks-Doherty, A. Powers et al. · Proceedings of the National... · 0 citations

Open access Jul 2026

Conformational Basis of Functionally Selective Allosteric Modulation of the Angiotensin II type 1 Receptor by Small Molecules

The DNA- encoded library screening-guided isolation and pharmacological characterization of the first small molecule AT1R allosteric ligands are reported, uncovering new mechanisms for precisely controlling the dynamic behavior of the AT1R with implications for drug development targeting this pathophysiologically impor...

Samuel Liu, Peng Xiao, M. Elgeti et al. · bioRxiv · 0 citations