Rong-Le Qiu

A direct, MFRN-independent Fe(II) transfer pathway at mitochondria-lysosome contacts

Mitochondrial iron homeostasis is fundamental to respiration and redox balance, and its dysregulation is implicated in neurodegeneration, cardiomyopathy, and metabolic diseases 1, 2. Although lysosomes harbor the major cellular iron reservoir 3, 4, the prevailing model holds that mitochondria acquire Fe(II) directly fr...