Natural killer (NK) cells eliminate target cells through antibody-dependent cell-mediated cytotoxicity (ADCC), initiated by CD16a (FcγRIIIa) recognizing the Fc region of antibodies bound to the target cell surface. While the recognition is considered to be driven by CD16a-Fc binding avidity, it fails to explain why Fc...
Rong Ma, K. Garcia, Bian-Xiao Cui et al.· Science Advances· 0 citations
Natural Killer(NK) cells eliminate target cells through antibody-dependent cell-mediated cytotoxicity(ADCC), initiated by CD16a(FcγRIIIa) recognizing the Fc region of antibodies bound to the target cell surface. While the recognition is considered to be driven by CD16a-Fc binding avidity, it fails to explain why Fc mul...
Rong Ma, K. Garcia, Bian-Xiao Cui et al.· bioRxiv· 0 citations
T cell antigen-specific immunity depends on pairwise interactions between T cell receptors and peptide- MHC, yet isolating the TCR-pMHC pairs that drive productive engagement remains a major obstacle for antigen-specific therapeutics and for decoding TCR specificity. We overcome this by co-encoding TCR and pMHC in a si...
L. Liu, Seung Won Shin, Kevin M. Joslin et al.· bioRxiv· 0 citations
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