Author

Rong-Quan He

3 papers indexed here

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Open access Aug 2026

CRISPR Screen Reveals Pathways and Factors Driving Tyrosine Kinase Inhibitor Resistance in Hepatocellular Carcinoma

Tyrosine kinase inhibitor (TKI) resistance severely limits clinical outcomes in hepatocellular carcinoma (HCC), highlighting the urgent need to elucidate its underlying molecular mechanisms. In this study, an unbiased genome‐wide CRISPR/Cas9 screening identified novel key factors related to the therapeutic responsivene...

Siyi Chen, Li-Hua Yang, Zi-Qian Liang et al. · Cancer Medicine · 0 citations

Open access Jan 2026

A Potential miR‐1246‐5p–H3K27ac–NOL12 Regulatory Axis and Its Putative Tumour‐Promoting Function in Hepatocellular Carcinoma

ABSTRACT Hepatocellular carcinoma (HCC) is a major cause of cancer‐related death worldwide. Although the nucleolar protein NOL12 has been implicated in HCC progression, its comprehensive expression patterns, clinical significance and regulation—particularly the potential involvement of miR‐1246‐5p and H3K27ac—are not f...

Li Xiao, Yu-Long Deng, Li-Na Liang et al. · IET Systems Biology · 0 citations

Open access Aug 2026

Clinical validation of KIF11 overexpression in colorectal cancer and its potential association with the antitumor effects of nitidine chloride

In vitro and limited xenograft data indicate that NC restrains CRC growth chiefly through the RAD21–KIF11 axis; KIF11 represents a promising preclinical target, though comprehensive systematic in vivo pharmacodynamic and translational animal validation remains absent in the current study and requires further independen...

Hui Li, Rui Lin, Ke-Jun Wu et al. · Hereditas · 0 citations