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Author

Rong-Rong Dou

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Open access Oct 2026

Structure-guided discovery of novel ERα-binding peptides with in vitro antiproliferative activity

Abstract Uterine leiomyoma (UL) is an oestrogen-dependent tumour, and ERα is closely associated with abnormal proliferation of UL cells. This study used structure-guided virtual screening of a 59,319-member peptide library, followed by molecular docking, MST, MD simulation, MM/PBSA analysis, MTT assays, ERα knockdown,...

Ting Guo, Yan Zhang, Shu-Dan Yang et al. · 0 citations
Aug 2026

Anti-centromere antibody positivity: a spectrum of clinical diagnoses and immunological patterns in a large patient cohort

Primary biliary cholangitis and Sjögren’s syndrome, not systemic sclerosis, are the most common definitive autoimmune diseases in the large anti-CENP-B-positive patient cohort, supporting their complementary role in clinical phenotyping and diagnostic evaluation.

Ya-Dan Li, Guang-Zhi Xiao, Rong-Rong Dou et al. · 0 citations

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