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Author

Ronit Witztum

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Feb 2026

Pathogenic tau in the mouse locus coeruleus produces noradrenergic hyperactivity and neuropsychiatric phenotypes reminiscent of early Alzheimer’s disease

It is demonstrated that pTau triggers phenotypes reflective of LC-NE hyperactivity in the early stages of AD pathogenesis, laying the foundation for the development of LC-based disease-modifying therapies to address neuropsychiatric manifestations.

Anuradha Korukonda, Harris E. Blankenship, K. Kam et al. · 3 citations
Open access Aug 2026

Effects of early adulthood chronic sleep disruption on late life cognition, brain pathology, and microglial reactivity in the PS19 mouse model of tauopathy

The improvement in spatial learning in late life following early adulthood chronic sleep disruption in PS19 mice would seem disentangled from an effect on tauopathy or neurodegeneration, but whether the behavioral consequence is related to the observed changes in hippocampal microglial density remains to be mechanistic...

Kerly Lozano, Haris Hillery, Kenny Vetter et al. · 0 citations

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