Open access
Aug 2026
A two-factor authentication mechanism licenses pilins for pilus assembly in gram-positive bacteria.
A "two-factor authentication" mechanism for pilus assembly in gram-positive bacteria is defined: class C sortases first verify pilin identity by forming a membrane-embedded interface that activates the enzyme, then they recognize the LPXTG motif to initiate loading and crosslinking.
Nicole A. Cheung, Reece M. Pawlaczyk, Brendan J. Mahoney et al.
· Proceedings of the National... · 0 citations