Roy R Parker

m6A depletion attenuates the macrophage type I interferon response

It is found that in THP1-derived and peripheral blood macrophages, m6A depletion with the METTL3 inhibitor STM2457 leads to enhanced proliferation of the human coronavirus OC43 and it is concluded that macrophages depend on m6A to support expression of interferon sensing machinery and in m6A’s absence, fail to mount as...