Author

Ruheng Wang

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Oct 2026

Interpretable Protein−Nucleic Acid Binding Site Prediction via Domain-Guided Multimodal Learning

Accurate identification of protein−nucleic acid binding sites is essential for elucidating molecular mechanisms and for enabling structure-based drug discovery. Existing computational approaches struggle to jointly model sequence, structure, and domain knowledge, which limits both predictive accuracy and interpretabi...

Wen-Yu Xi, Ru-Heng Wang, Xiu-Cai Ye et al. · ACS Synthetic Biology · 0 citations

Open access Aug 2026

NanoPrism: A Taxonomy-Guided Pipeline for Rapid Functional Profiling of Oxford Nanopore Long-Read Metagenomes

NanoPrism offers a computationally efficient option for taxonomy-guided functional profiling of bacterial isolates and defined microbial communities and offers validation on complex clinical and environmental metagenomes, broader forms of taxonomic-classification error, and dedicated fungal benchmarks remain necessary.

Jiwoong Kim, Shuheng Gan, Harish Jawahar et al. · DNA · 0 citations

Sep 2026

Deciphering T-cell receptor-antigen recognition through interpretable residue-level interaction modeling.

Evaluation across multiple settings indicates that TCR-IFNet achieves competitive performance compared with existing methods, with higher AUPRC observed on both antigen-specific and healthy-sourced datasets, as well as improved results on independent test sets.

Wen-Yu Xi, Ru-Heng Wang, Xiu-Cai Ye et al. · International Journal of Bio... · 0 citations