Review
Open access
Sep 2026
Megakaryocytes in myelofibrosis: mechanisms of fibrotic niche remodeling and therapeutic implications
Myelofibrosis is a clonal myeloproliferative neoplasm characterized by progressive remodeling of the bone marrow microenvironment. Megakaryocyte (MK) abnormalities are defining histological features of prefibrotic and overt primary myelofibrosis and contribute to disease pathogenesis. Dysplastic MKs can directly modify...
Jian-Song Huang, Xiao-Yue Yin, Xiao-Feng Shi et al.
· Biomarker Research · 0 citations