Open access
Oct 2026
M6A Demethylase FTO Targets Pcsk9 to Inhibit Vascular Calcification in Chronic Kidney Disease.
BACKGROUND FTO (fat mass and obesity-associated) protein, a key N6-methyladenosine demethylase, plays a critical role in cardiovascular disease. However, its function in vascular calcification remains poorly understood. METHODS High phosphate (Pi) was used to induce calcification in vascular smooth muscle cells (VSMC...
Yu-Chen Xie, Huan Zhao, Lan Lan et al.
· Arteriosclerosis, Thrombosis... · 0 citations