Ru-Peng Dai

Biocatalytic Redox Cascade Enabled Site-Selective Direct β-Alkylation of Cyclopentanones

Alkylation of carbonyl compounds is among the most widely practiced transformations in organic synthesis. While extensive methods exist for functionalization at the ipso and α-positions, direct β-alkylation remains a significant challenge, especially for cyclic ketones. Furthermore, catalyst-controlled site selectivi...