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Author

Ru-Qi Zhang

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Open access Aug 2026

α-KG conformationally stabilizes nuclear GLUD1-SNAIL complex to fuel trans-endothelial migration in metastasis

Trans-endothelial migration (TEM) is a critical rate-limiting barrier in tumor metastasis, yet its mechanistic basis remains poorly defined. Here we show that α-ketoglutarate (α-KG) and its metabolic enzyme glutamate dehydrogenase 1 (GLUD1) constitute a pivotal regulatory axis governing this process. Mechanistically, G...

Jia-Wen Cui, Nuo Xu, Rong-Yu Cao et al. · 0 citations
Open access Sep 2026

Effects of L-selenomethylselenocysteine-fortified milk powder on immune homeostasis, intestinal integrity, and gut microbiota in immunosuppressed mice.

Immunosuppression is strongly associated with impaired intestinal health and perturbations in gut microbial composition. This study aimed to evaluate the regulatory effects of L-selenomethylselenocysteine (L-SeMC) fortified milk powder on immune function and gut microbiota in cyclophosphamide (CTX)-induced immunosuppre...

Ru-Qi Zhang, Hui-Qing Lu, Su-Mei Bi et al. · 0 citations

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