Ruben J. Cauchi

Motor dysfunction phenotypes in a drosophila model validate DAO as an ALS gene

Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterised by progressive motor neuron (MN) loss. Although rare pathogenic variants in the D-amino acid oxidase (DAO) gene have been proposed to cause familial ALS, inconsistent findings across mammalian models have hindered functiona...