Thyroxine Enhances Breast Cancer Cell Survival and Proliferation via TRβ1-Dependent PI3K/AKT Signaling.
Thyroid hormones (TH) influence tumor biology through both genomic and non-genomic mechanisms. Specifically, thyroxine (T4) activates signaling pathways linked to cancer progression through interactions with nuclear receptors, such as TRβ1, and membrane receptors, including integrin αvβ3. Nevertheless, the precise role...