A Zika Virus Vaccine with E Protein Fusion Loop Mutations Protects via CD8+ T Cells
There are currently no effective vaccines against Zika virus (ZIKV). Candidate vaccines target the ZIKV envelope (E) protein, the major target of anti-ZIKV neutralizing antibodies (nAbs). Here, we utilized DNA and RNA platforms to compare virus-like particle vaccines with premembrane (prM) and E expressed either in the...