Abstract B065: Bioactive Compounds Derived from Alcea rosea Suppress KRAS-Driven Signaling and Cancer Stem Cell Plasticity in Pancreatic Ductal Adenocarcinoma
Activating KRAS mutations occur in more than 90% of pancreatic ductal adenocarcinoma (PDAC) cases and are major drivers of tumor progression, therapeutic resistance, and poor clinical outcomes. Persistent activation of the RAF/MEK/ERK signaling cascade promotes cancer stem cell (CSC) maintenance and tumor plastic...