Rui-Chu Gu

UniCure: A multi-modal model for predicting personalized cancer therapy response.

UniCure is presented, a multi-modal model that combines biological and chemical foundation models to predict drug-induced transcriptomic responses across diverse cell and tissue contexts, enabling individualized drug ranking.

Precise DNA base editing using AlphaFold3-based contact modelling

MEGA-ODE: Learning Biologically Structured and Navigable Continuous Perturbation Dynamics from Sparse Omics

In a COVID-19 patient cohort, predicted intermediate profiles improved retrospective disease-stage stratification relative to observed profiles alone, while expert programs highlighted immune and inflammatory signals associated with severity, and these results support biologically structured continuous-time modeling fo...