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Open access Sep 2026

Activation of TREM2 via single-domain antibodies improves synaptic and cognitive function in 5×FAD mice.

Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder, and dysfunction of triggering receptor expressed on myeloid cells 2 (TREM2) in microglia increases AD risk. TREM2 activation promotes protective microglial functions and mitigates AD pathology. Although TREM2-activating antibodies show therapeut...

Xiao-Xiao Yu, Qiao-Yun Ren, Yan-Chun Gao et al. · 0 citations
Open access Sep 2026

Directing GABAergic neuronal identity from human iPSCs through developmental patterning.

It is shown that the chromatin state of the starting population constrains the neuronal identities specified by ASCL1 and DLX2, and it is demonstrated that the recurrent p.Tyr719∗ mutation disrupts interneuron maturation and subtype-associated transcriptional programs and impairs inhibitory synaptic transmission in hum...

Rui-Qi Hu, Linda L. Boshans, Yi-Ran Tao et al. · 0 citations

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