The parent 15-mer peptide exhibited no activity against Pseudomonas aeruginosa. Previous studies demonstrated that neither all-hydrocarbon stapling (i, i + 4 octenyl bridge) nor divinylpyrimidine exogenous linker cyclization conferred anti-P. aeruginosa activity upon this sequence. In the present study, this peptide se...
Although the inhibitors targeting PARP are successfully applied in the clinical treatment of tumors, the further application of PARP inhibitors is limited by reasons such as multi-drug resistance, the DNA replication fork function recovery and relatively low proportion of BRCA1/2-mutant tumors. There have been relevant...
Yi-Ru Bai, Rui-Fang Li, Jing-Ru Kang et al.· European journal of medicina...· 0 citations
This review comprehensively summarises the development progress of new drugs approved in 2025, including molecular design, structural modification, structure-activity relationship, and enhancement of drug-like properties to offer valuable insights to pharmaceutical chemists and bring inspiration for future research.
Yi-Ru Bai, Rui-Fang Li, Xin-Hui Zhang et al.· Journal of Enzyme Inhibition...· 2 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
