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Oct 2026

Trichoxanes A and B: Molecular Networking-Guided Discovery of Cage-Like Sorbicillinoids as Mycobacterium tuberculosis GlmU Inhibitors

Trichoxanes A (1) and B (2), two novel sorbicillinoids featuring a unique cage-like 2,7-dioxa-pentacyclo[7.4.0.03,8.05,13.06,10]tridecane scaffold, were isolated from Trichoderma reesei via a molecular networking strategy. Their structures were elucidated by spectroscopic analyses, CASE, DP4+ NMR calculations, and EC...

Rui Jiang, Xin-Yu Zheng, Xing-Piao Jin et al. · 0 citations
Sep 2026

Multimethod-guided discovery of novel α-pyrone dimers with cardiomyocyte-protective activity against cold ischemia injury from the coral-derived Talaromyces sp. TJ403-AL05.

Guided by molecular networking, HSQC-based DeepSAT, and SMART analyses, a chemical investigation of the coral-derived fungus Talaromyces sp. TJ403-AL05 led to the isolation and identification of taladipyrones A-I (1-9), a series of new α-pyrone dimers with four distinct skeletons. Among these, compounds 1 and 9 represe...

Han-Xiao Zeng, Yaxing Wang, Chen-Meng Huang et al. · 0 citations
Open access Sep 2026

GNPS-guided discovery of eremophilane sesquiterpenoids from Penicillium roqueforti and their phytotoxic activities.

The GNPS (Global Natural Products Social Molecular Networking) strategy enable the targeted isolation of eremophilane sesquiterpenoids from Penicillium roqueforti, a fungus isolated from the rhizosphere soil of Hypericum beanii N. Robson collected in the Shennongjia Forestry District, Hubei Province, China. The isolate...

Shu-Yuan Mo, Xiang-Man Shu, Jie Zhao et al. · 0 citations

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