Biomolecular phase separation has emerged as a key organizing principle in macroautophagy (hereafter autophagy). In mammalian cells, phase‐separated condensates not only serve as substrates for selective degradation, but also act as dynamic platforms for cargo recognition, signaling integration, and autophagosome assem...
Yuan-Qiang Lin, Mingran Dai, En-Yong Dai et al.· Advancement of science· 0 citations
Leucine zipper transcription factor-like 1 (LZTFL1) is identified as a key regulator of ferroptosis that rewires glutathione (GSH) metabolism and is highlighted as a potential biomarker and a therapeutic target for enhancing ferroptosis-based cancer therapy.
Xiangfei Xue, Xiao Zhang, Qianjun Zhou et al.· Molecules and Cells· 0 citations
This Review synthesizes current understanding of the core molecular mechanisms governing ferroptosis, including dysregulated iron metabolism, lipid peroxidation pathways, and failure of antioxidant defense systems, and reviews the rapidly expanding spectrum of ferroptosis-based therapeutic strategies.
Yang-Chun Xie, Luting Chen, Yu-Hua Feng et al.· Cancer Letters· 0 citations
Findings identify a lactate-KAT2B-H3K18la epigenetic axis that orchestrates the long-term reprogramming of CCR5hi monocytes, highlighting CCR5hi monocytes as a promising therapeutic target for modulating innate immunity against lethal sepsis.
Lingqi Xu, Wenyan Hao, Yingyi Yang et al.· Science Advances· 0 citations
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