HSPA1A promotes immune-evasive colorectal liver metastasis through post-transcriptional stabilization of APP mRNA.
Colorectal cancer (CRC) liver metastasis remains a major clinical challenge, particularly in microsatellite-stable tumors that respond poorly to immune checkpoint blockade. Whether tumor cell-intrinsic stress programs actively promote immune evasion during hepatic colonization remains incompletely understood. Here, we...