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Author

Ruirui Shi

2 papers indexed here

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Review Sep 2026

A Unified Mechanistic Framework for Copper Toxicity in Neutrophils: Metabolic Rewiring, Cell-Death Crosstalk, and Immune Dysfunction.

By tracing individual routes from copper-pool disruption to defined cellular and tissue-level outcomes, this model distinguishes systemic copper overload from inflammatory copper redistribution and identifies the measurements required to establish copper-dependent neutrophil pathology in human disease.

Rui-Rui Shi, Si-Yue Chen, Ting-Ting Chen et al. · 0 citations
Open access Jul 2026

ETV6 Rearrangement Suppresses CDKN1B Transcription by Disrupting an Intragenic Super-Enhancer in Acute Lymphoblastic Leukemia.

It is demonstrated that ETV6 functions as a regulatory element via ETV6-SE in ALL, with CDKN1B as a key target and CRISPR interference and knockout experiments revealed the core enhancer region within ETV6-SE responsible for CDKN1B regulation.

Wenqian Xu, Xiaofang Ma, Xue Sun et al. · 0 citations

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