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Aug 2026

Conformational Features of Aβ25-35 and Its Mutants Suggest Toxic Structural Determinants: Insights from REST2 Simulations.

It is proposed that the disassembly propensity of dominant β-barrels governs their transition from off-pathway states to cytotoxic oligomers, and N-terminal domain exposure in on-pathway intermediates modulates peptide-membrane interactions.

Y. Mo, Yong-Hui Hou, Rui Su et al. · 0 citations

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