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Preprint Aug 2026

Non-Crossing Deep Quantile Regression for Distributional Survival Prediction

In survival analysis the way covariates act on the risk of an event often differs between early and late failure times, yet hazard- and mean-based summaries collapse this variation into a single number. Quantile-based modeling instead describes the full conditional distribution on the original time scale, but existing...

Shuaibin Huang, Zhe Qu, Zhaowei Hua et al. · 0 citations
Open access Aug 2026

Mechanisms of resilience to autosomal dominant Alzheimer’s disease via oligogenic modulation of rare variants in the entorhinal cortex

Two PSEN1 E280A carriers have presented extreme protection against autosomal dominant Alzheimer’s disease (ADAD), with over two decades of delay for dementia onset. One of them, a male heterozygous for the RELN-COLBOS protective variant showed increased neuronal density in the entorhinal cortex 1. We conducted a deep p...

Yassir El-Amri, N. Villalba-Moreno, Julia A. Urban et al. · 0 citations

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