Open access
Aug 2026
Mechano-Piezoelectric F-Peptide Hydrogels Enable In Situ Stem Cell and Immune Niche Modulation for Cartilage Regeneration
The trifluoromethyl-modified, 4-octyl itaconate (4–OI) loaded formulation reverses osteoarthritis via PI3K/AKT activation and Wnt/β–catenin suppression, as shown by improved Osteoarthritis Research Society International (OARSI) scores, bone microarchitecture, and cartilage matrix.
Xuekai Song, Zhao-Wen Xu, Si-Qi Zhang et al.
· bioRxiv · 0 citations