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Rui-Xue Chen

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Review Open access Aug 2026

Decoding the Bile Acid-Mitochondria Axis: Implications for Disease Management and Therapeutic Opportunities.

Bile acids, as cholesterol metabolites, orchestrate a regulatory network with mitochondrial quality control (MQC) through nuclear receptor FXR, membrane receptor TGR5, and other signaling molecules, modulating mitochondrial biogenesis, dynamic equilibrium, selective autophagy, and redox homeostasis. TGR5 promotes PGC-1...

Xue-Ru Jia, Ze-Han Zhang, Xiao-Yu Lin et al. · 0 citations

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