Aug 2026
A Biomimetic Nanoplatform Alleviates Depression via GRP75-Targeted Mitochondria-Associated Endoplasmic Reticulum Membranes Disassembly and Nanozyme-Driven ROS Scavenging.
In mice subjected to chronic social defeat stress (CSDS), P/F-Rg1@M effectively alleviated depressive-like behaviors, including social avoidance and anhedonia, and provides a nanotherapeutic approach that integrates structural organelle remodeling with microenvironmental regulation for psychiatric disorders.
Wen-Fei Wang, Pengxiang Zhang, Ye Peng et al.
· Advanced Healthcare Material... · 0 citations