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Author

Ruijie Fu

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Aug 2026

Click-chemistry-mediated modulation of CRISPR-Cas12a activity through activator modification.

A simple and robust strategy using dibenzocyclooctyne-mediated click chemistry to modulate CRISPR-Cas12a activity and shows that DBCO-modified activators can regulate CRISPR-Cas12a cleavage in three distinct states: maintain, enhance, and suppress.

Ruijie Fu, Chenggong Zhu, Jinjie Hou et al. · 0 citations