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Ruiyuan Liu

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Aug 2026

Red-emissive fluorescent probes based on PET mechanism for highly sensitive detection and multi-scenario imaging of thiophenol.

Thiophenol (PhSH) is a highly toxic aromatic thiol endangering ecosystems, food safety, and human health. Traditional detection methods are limited by instrument dependence and inability for real-time imaging. This study developed a red-emitting fluorescent probe, TTCP-DN, based on the PET mechanism. The probe employs 5-(4-diphenylamino)benzothiophene as the fluorophore and 2,4-dinitrophenoxy as the PhSH-specific recognition moiety, achieving mitochondrial targeting via a pyridine salt. Without PhSH, fluorescence is quenched; upon PhSH-induced reaction, fluorescence restores at 623 nm. The probe has low detection limit (37.8 nM), large Stokes shift (153 nm), good biocompatibility, and high selectivity. It was applied for mitochondrial imaging in 4 T1 cells, qualitative detection and semi-quantitative concentration trend analysis of PhSH in zebrafish, plant tissues, environmental, food and biological samples (recoveries 95-105%), and fabricated into portable paper-based test strips. This work provides a versatile PhSH detection tool and a paradigm for targeted probes of toxic aromatic pollutants.

Yukun Zhang, Xiaoli Li, Ruiyuan Liu et al. · 0 citations
Open access Jul 2026

Multifunctional Manganese Oxide Nanocomposite Hydrogel With Synergistic Reactive Oxygen Species‐Scavenging, Oxygen‐Generating, Immunomodulatory, and Photothermal Antimicrobial Activities for Enhanced Diabetic Wound Healing

This multifunctional hydrogel integrates ROS scavenging, self‐sustained oxygenation, immunomodulation, and photothermal antibacterial action, offering a synergistic, innovative strategy for diabetic wound treatment.

Zhi Xu, Xiaodong Luo, Jingxia Wu et al. · 0 citations
Aug 2026

A mussel-inspired hydrogel matrix with photothermal activity and phycocyanin-modified cerium oxide nanoparticles with antioxidant activity for synergistic infected wound healing.

A multifunctional composite hydrogel (GelDA/OPL) with excellent adhesion, self-healing properties, injectability, and photothermal antibacterial activity through Schiff base crosslinking between dopamine-modified gelatin (GelDA) and oxidized pullulan (OPL) is constructed.

Chen Zhang, Surui Yang, Zhi Xu et al. · 0 citations
Open access Aug 2026

Cerium molybdate-doped polyaniline nanoplatform for GSH-depletion-enhanced chemodynamic/NIR-II photothermal synergistic therapy via ferroptosis and immune activation

Cerium molybdate-doped polyaniline nanoparticles are developed to enable a synergistic combination of photothermal therapy (PTT) and CDT, thereby triggering immunogenic cell death (ICD) and enhancing antitumor immunity and presenting a robust nanoplatform integrating chemodynamic and photothermal therapies for potent cancer immunotherapy.

Yulin Kuang, Cheng Lu, Bolan Yu et al. · 0 citations