Author

Ruo-Lin Zhang

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Open access Sep 2026

Nrsn1–Smarcc1 Coupling Regulates Neural Stem Cell Differentiation and Chronic‐phase Recovery After Ischemic Stroke

ABSTRACT Stroke remains a leading cause of long‐term neurological disability worldwide, largely due to irreversible neuronal loss and the limited regenerative capacity of the adult mammalian brain. Neural stem cells (NSCs) in the adult brain possess the potential to generate new neurons after injury, yet the molecular...

Ruo-Lin Zhang, Chang Liu, Yu-Neng Zhou et al. · Advancement of science · 0 citations

Oct 2026

CYTIP promotes pro-inflammatory activation of microglia through interaction with LRRFIP2 following ischemic stroke.

Microglia-mediated neuroinflammation is a critical contributor to cerebral ischemia/reperfusion (I/R) injury. However, the functional heterogeneity of microglia presents significant challenges in defining therapeutic signatures. By integrating single-nucleus RNA sequencing (snRNA-seq) of a mouse middle cerebral artery...

Zhi-Hao Yang, Yi-Qi Wang, Yu-Neng Zhou et al. · Cellular Signalling · 0 citations