Obesity and related metabolic disorders have surged globally, and are mechanistically interconnected through dysregulated energy and lipid metabolism pathways. Current incretin-based obesity treatments act to decrease food intake, but are associated with gastrointestinal side effects and muscle wasting. Here, we identi...
Justin Y. Lee, Chi Zhu, Melissa A. Boldridge et al.· Science Advances· 1 citation
It is shown that antisense oligonucleotide-mediated inhibition of miR-128-3p restores muscle mass and function in aged mice, improves cardiac function while limiting adverse remodeling following myocardial infarction, and ameliorates skeletal and cardiac muscle pathology in mouse and pig models of Duchenne muscular dys...
Melissa A. Boldridge, Lei Xu, Xiao-Yin Wang et al.· bioRxiv· 0 citations
Findings uncover a previously unrecognized QS-regulated metabolic—epigenetic axis through which PA manipulates host immunity, highlighting lactate metabolism as a potential therapeutic target for combating chronic Pseudomonas infections.
Arijit Chakraborty, Arijit Chakraborty, Shifu Aggarwal et al.· Journal of Immunology· 0 citations
An input-specific translatome screen is designed to identify regulators of experience-dependent PV IN plasticity genes (XPGs) in the CA3/CA2 subregion of adult hippocampus and shows that experience-dependent PV IN plasticity is a convergent mechanism for NDD risk genes that can be re-instated in adulthood to reverse de...
Yu-Tzu Shih, J. Alipio, Z. Klaft et al.· Nature· 2 citations
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