Author

Ruxandra Bighiu

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Single-cell proteomic profiling of cochlear hair cells and mechanotransduction interaction mapping

Hearing loss is a major and growing global health burden, often resulting from irreversible damage to cochlear hair cells, the sensory cells responsible for mechano-electrical transduction (MET) in the inner ear. Although genetic and transcriptomic studies have extensively characterised these cells, protein-level mecha...

Ruxandra Bighiu · 0 citations

Open access Sep 2026

The hearing-essential intracellular domain of PCDH15 reveals a new layer of auditory mechanotransduction

Current models of mechanotransduction in inner-ear hair cells explain how force is transmitted through the extracellular tip link but provide little insight into how force is propagated beneath the plasma membrane. Although the CD2 isoform of PCDH15 has been shown to be essential for hearing in mature mammalian hair ce...

J. Van de Velde, Ruxandra Bighiu, Nabanita Mandal et al. · bioRxiv · 0 citations