Open access
Sep 2026
TFIIS enhancement of Pol II cleavage is under kinetic control
Abstract The eukaryotic RNA polymerases (Pols) contain subunits or interact with trans-acting factors that confer robust endonuclease activity. A12.2 and C11 are subunits of Pol I and Pol III, respectively. Pol II, however, recruits transcription factor IIS (TFIIS). This evolutionary divergence of A12.2 and C11 being b...
Ryan M. Requijo, N. K. Maluf, D. Schneider et al.
· Nucleic Acids Research · 0 citations