Author

S. Abdel-Ghany

3 papers indexed here

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Open access Aug 2026

Targeted Folate-Chitosan Nanoformulations of Quercetin and Coriandrum sativum Reprogram Breast Cancer Hallmarks by Silencing Stemness, Cell Cycle, Angiogenic, and Metastatic Networks

Background/Objectives: This study engineered and evaluated a targeted, folate-functionalized chitosan nanoparticle (CS-FA NP) delivery system to enhance the therapeutic efficacy of standard quercetin and Coriandrum sativum seed extract against breast cancer. Methods: Phytochemical profiling confirmed a 14% crude yield...

Nariman Nabil, Hussein Sabit, J. Almulhim et al. · Pharmaceuticals · 0 citations

Review Open access Aug 2026

Cancer-associated adipocytes: metabolic reprogramming, crosstalk and therapeutic implications in tumor progression

Adipose tissue, once considered a passive fuel store, is now recognized as a dynamic endocrine organ that shapes cancer behavior. Within the tumor microenvironment (TME), cancer-associated adipocytes (CAAs) undergo marked reprogramming—losing large lipid droplets, adopting fibroblast-like features, and intensifying lip...

Jin-Min Shi, S. Abdel-Ghany, Mariam M Abdelfattah et al. · Signal Transduction and Targ... · 0 citations

Review Open access Sep 2026

Epigenetic Plasticity in Triple-Negative Breast Cancer: Mechanisms of Therapy Resistance, Biomarkers, and Therapeutic Vulnerabilities

Triple-negative breast cancer (TNBC) is an aggressive and clinically heterogeneous breast cancer subtype characterized by the absence of estrogen receptor, progesterone receptor, and HER2 overexpression, limited targeted treatment options, early relapse, and frequent development of therapy resistance. Although TNBC oft...

A. Alaa, Salma A. B. El-Din, Mohannad A. Farrag et al. · Biomedicines · 0 citations