In this study, we present a comprehensive structural analysis of four distinct chemical libraries: FDA‐approved drugs, blood‐brain barrier (BBB) permeable agents, natural products (UNPDA), and human metabolites. Our multidimensional profiling reveals fundamental divergences in molecular architecture. While synthetic dr...
V. Masand, S. Al-Hussain, Mohammed Sharique Ahmed Quadri et al.· ChemMedChem· 0 citations
Abstract The clinical translation of cancer nanomedicine remains constrained by inefficient intracellular delivery, poor subcellular specificity, and limited tumor accumulation, highlighting the need for more precise drug delivery strategies. Organelle-targeted nanocarriers have emerged as a promising platform for enha...
Han-Gen Zhang, Jia Guo, Xin-Miao Wang et al.· International Journal of Nan...· 0 citations
Compound 4j represents a promising lead candidate for the development of novel EGFR-targeted anticancer agents and demonstrated remarkable potency with an IC50 value of 0.27 µM.
Amani M. R. Alsaedi, Alaa M. Abu Alnjaa, Amel S. Younes et al.· Future Medicinal Chemistry· 0 citations
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