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Oct 2026

Integrated computational and experimental identification of Aurora A kinase inhibitors for breast cancer therapy.

The present study aimed to identify potential Aurora A kinase (AURKA) inhibitors using an integrated computational and experimental approach. A total of 281 curated AURKA inhibitors from the ChEMBL database, with IC50 ≤ 1 nM, were analysed using physicochemical descriptors and clustering techniques, with K-means showin...

J. Singh, S. Mishra, I. Irfan et al. · 0 citations
2026

Design to Neuroprotection: A Blood Brain Barrier Permeable Selective HDAC3 Inhibitor Active against Chemical and Viral Insults

Neuronal loss in neurodegenerative diseases is mediated by oxidative stress, neuroinflammation, and epigenetic dysregulation, with histone deacetylase 3 (HDAC3) playing a central role in inflammatory signaling and neuronal damage. We...

Darakhshan Begum, Sanjeev Regula, Suryansh Sengar et al. · 0 citations

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