Summary Brain-derived neurotrophic factor (BDNF) plays an essential role in neuronal growth and maturation, as well as in maintaining synaptic plasticity. Dysregulated BDNF levels significantly increase the risk of neurological and metabolic disorders. In type 2 diabetes mellitus, several pathological mechanisms, inclu...
Garima Chandak, B. Kumar, Shubham Kumar et al.· iScience· 0 citations
Findings reveal that isatin is a useful framework for developing new anticancer drugs, and nano‐formulation drug delivery systems with new drug signaling pathways will be promoted to increase bioavailability and targeted delivery, especially in solid tumors.
This review covers advances in designing and synthesizing bioactive heterocycles, highlighting structure-based drug design (SBDD) and ligand-based drug design (LBDD) approaches with computational modeling and Artificial Intelligence (AI) to find potent, selective molecules with good Absorption, Distribution, Metabolism...
Debajit Dewan, Bhupender Nehra, R. Nath et al.· Future Medicinal Chemistry· 0 citations
A contemporary assessment of biological macromolecule research is provided, highlighting how technological advancements continue to fill the existing bridge and integrate the prior understanding of complex biomolecular systems while addressing persistent technical challenges in their characterization, with finesse.
Rabab Fatima, Bhupender Nehra, Biplab Debnath et al.· Critical reviews in analytic...· 0 citations
Global fruit production reached 953.8 million tonnes in 2024, generating peel residues of 15%-50% of fruit weight that are largely discarded despite containing polyphenols, carotenoids, dietary fiber, and enzymes of commercial value. Existing reviews address this in fragments, covering extraction, green solvents, or fo...
S. Ashique, Ashish Garg, Md Sadique Hussain et al.· Preparative Biochemistry & B...· 0 citations
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