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S. Baek

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Open access Sep 2026

Transcriptional modulation of β-Secretase ameliorates amyloid pathology and cognitive deficits in Alzheimer’s disease models

its pleiotropic pharmacology, CHX should be regarded here as a nonselective pharmacological probe rather than a repurposing-ready AD therapeutic. That said, the effect does not appear to be simply broad, nonspeci fi c suppression. Components of the γ -secretase complex were unchanged by CHX, and the reduction in gliosis...

Jinsu Park, H. Bae, Yoonsuk Cho et al. · 0 citations

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