Development and Evaluation of Ticagrelor Solid Dispersion Tablets Using PVP K30, PEG 6000 and HPMC E5 for Dissolution Enhancement
Ticagrelor is an orally active P2Y12 receptor antagonist used in the management of acute coronary syndrome, but its oral performance is limited by poor aqueous solubility and variable dissolution behavior. The present study aimed to develop ticagrelor solid dispersion tablets using hydrophilic carriers in order to impr...