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Author

S. Bass-Stringer

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Open access Aug 2026

The Drp1 inhibitor DRP1i2 confers cardioprotection against doxorubicin-induced cardiotoxicity

It is demonstrated that DRP1i2 confers cardioprotection while maintaining anticancer efficacy via modulation of Drp1-dependent mitochondrial dynamics, supporting mitochondrial fission as a targetable pathway to mitigate doxorubicin-induced cardiotoxicity.

Yali Deng, S. Bass-Stringer, S. Bond et al. · 0 citations
Open access Aug 2026

High-throughput screening in hiPSC-cardiac models reveals cardiomyocyte-specific cell cycle regulatory mechanisms

A dual-reporter and a high-throughput image-based pipeline are developed and a cardiomyocyte-selective pro-proliferative compound is identified as GDC-0339, uncovering cardiomyocyte-specific mechanisms governing the cell cycle that are potentially druggable.

Francesca Butera, Bryce Hassett, Rachel Morris et al. · 0 citations

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