Open access
Sep 2026
An evolutionarily conserved interferon-responsive oligodendroglial state emerges during white matter aging
White matter dysfunction is a hallmark of brain aging and often precedes overt neurodegeneration, yet the cellular alterations connecting aging to white matter dysfunction remain poorly understood. Here, we establish the killifish optic nerve as a translational model of white matter aging by integrating transcriptomic,...
Pieter-Jan Serneels, Julie D. De Schutter, Luca Masin et al.
· bioRxiv · 0 citations