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S. Bhatnagar

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Jul 2026

Biotin protein ligase C-terminal domain arginines are critical for ATP interaction & biotinyl-5'-AMP formation.

Electrostatic interactions between arginines and phosphates are central to numerous biological processes. Here, using an integrated approach combining mutagenesis, activity measurements, molecular dynamics (MD) simulations, and NMR, we demonstrate that arginines present in the C-terminal domain of Biotin protein ligase...

S. Bhatnagar, Debodyuti Sadhukhan, Manoj Kumar Rajak et al. · 0 citations

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