Sep 2026
A pyridone-fused imidazo[1,2-a]pyridine hybrid binds to tubulin at the vinblastine site, depolymerizes microtubules and inhibits Cancer cell proliferation.
C-18 is validated as a rare small molecule that targets the tubulin vinblastine site via competitive displacement, offering a distinct chemical blueprint for microtubule-targeted oncology drug discovery.
Mehak Sood, Tuhin Sarkar, Kanchan Chaurasiya et al.
· Bioorganic chemistry (Print) · 0 citations