Host genetic variation is a key determinant of malaria susceptibility, particularly in endemic regions where intense transmission has driven strong selective pressures on red blood cell-related genes. However, Senegalese and other African populations remain underrepresented in genomic studies, limiting population-speci...
Babacar Souleymane Sambe, A. Diagne, J. Phelan et al.· International Journal of Mol...· 0 citations
TB-Profiler is a user-friendly bioinformatics tool developed to genotypically profile
Mycobacterium tuberculosis
from next-generation sequencing data. It provides predictions of drug resistance and assigns sub-lineages to support clinical management of tuberculosis (TB) and public health surveillance. The pla...
J. Phelan, Waritta Sawaengdee, Joseph Thorpe et al.· Genome Medicine· 0 citations
The emergence of antimalarial drug resistance threatens malaria control and elimination efforts in Africa. Ethiopia, once a success story in case reduction, is now experiencing a resurgence. Here we examine key drug resistance genes (Pfmdr1, Pfcrt, Pfk13, Pfdhfr and Pfdhps) and mitochondrial genomes from 605 Plasmodium...
A. Letebo, L. Vanheer, Mengst Engdaw et al.· Nature Microbiology· 0 citations
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