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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

S. Canesi

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2 papers indexed here

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Open access Sep 2026

CDK12/13 inhibition overcomes platinum resistance by impairing RNA metabolism

Epithelial ovarian cancer (EOC) is a highly lethal disease characterized by a high rate of platinum (PT)-resistant recurrence. Dysregulation of transcriptional and alternative splicing (AS) has been suggested as a possible mechanism of PT resistance involving transcriptional cyclin-dependent kinases (CDKs). We report t...

Ilenia Pellarin, Valentina Rossi, R. Margiotta et al. · 0 citations
Open access Sep 2026

Combination of PARPi and topoisomerase I inhibitors is highly effective in olaparib-resistant ovarian cancer

High-grade serous ovarian carcinoma (HGSOC) often shows an initial response to poly (ADP-ribose) polymerase inhibitors (PARPi) such as olaparib, particularly in tumors with defects in homologous recombination (HR), but resistance to these drugs is a major clinical challenge. To address this, we screened over 1400 FDA-a...

M. Chiappa, V. Villa, F. Sias et al. · 0 citations

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