S. Chaudhary

The protein-water H-bond network for bacterial response regulator REC domain activation

The bacterial response regulator (RR) superfamily is activated by aspartyl phosphorylation of the receiver (REC) domain for diverse functions. Crystal structures of the enteric CheY chemotaxis RRs (CheYes) have revealed water-residue hydrogen bonds (H-bonds) essential for activation. Here, we compared the H-bond networ...

Quantitative Assessment of Aquatic Microplastic Pollution in an Urban Drainage System of Pakistan

TISON: A Web Server for Omics-driven Integrative Cancer Modeling & Simulations towards Personalized Medicine.

Next-generation sequencing (NGS) has catalyzed the generation of individualized multi-omics datasets, potentiating precise molecular insights into cancer initiation, progression, and metastasis. The subsequent data analytics have necessitated the development of computational pipelines that couple patient-specific omics...

Age-Associated NAD+ Decline and Mitochondrial Dysfunction Predispose Cells to a Reversible Tumor-Permissive Metabolic State

It is shown that mitochondrial aging creates a vulnerable metabolic environment that, combined with specific triggers, can push cells toward early tumorigenesis, offering a new framework for understanding and intervening in age-related cancer risk.