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Author

Sandra Chiu

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Open access Sep 2026

A highly potent bispecific antibody confers complete protection against SFTSV in preclinical models.

Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging bunyavirus that causes severe human disease, with a case fatality rate of up to 30%. However, no licensed therapeutics are currently available for clinical use. Here, we identified two SFTSV neutralizing nanobodies (Nbs), N2C1 and N2D2, which inhi...

Xiao-Ping Guo, Fu-Jian Wan, Wu-Jian Li et al. · 0 citations
Open access Oct 2026

A dual-glycoprotein-targeting bispecific nanoantibody confers potent neutralization against Nipah virus.

Nipah virus (NiV) is a biosafety level 4 pathogen that has consistently posed a significant threat to public health. The two envelope proteins on the viral surface, the receptor-binding protein (RBP) and the fusion (F) protein, are the primary targets of neutralizing antibodies. However, the use of antibodies targeting...

Sheng-Dong Wang, Xing-Hai Zhang, Hai-Wei Zhang et al. · 0 citations

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